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(b) The time line of the patching and testing protocol.

(c) Measurement of binocular balance using a binocular combination task after patching of the amblyopic eye for each of eight observers with amblyopia (S1–S8).

We show that a short period of patching the amblyopic eye with a diffuser enhances the amblyopic eye's contribution to the binocular percept, suggesting that the binocular plasticity in adults with amblyopia can occur rapidly and is able to reverse well-established neural changes that occurred in childhood.

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Data points below the x-axis indicate a strengthening of the previously patched eye's contribution to the binocular percept.

Both the control groups (control group1: blue lines, average results of five normal controls, with a randomly chose eye as the patched eye and the contrast of the stimulus in the unpatched eye being fixed at 64%; control group 2: green lines, average results of four additional normal controls, with the undominant eye chosen as the patched eye and the contrast of the stimulus in the patched eye being fixed at 100%) and amblyopes (red lines, separate panels for eight amblyopes, with the amblyopic eye chosen as the patched eye and the contrast of the stimulus in the patched eye being fixed at 100%) displayed a strengthening of the previously patched eye's contribution to the binocular percept.(a) A schematic of the experimental protocol.

It has also recently been shown that binocular functions can be restored in adults with amblyopia following an intensive period of dichoptic training aimed at getting the two eyes to work together.

Here we apply this approach to adults with amblyopia to assess whether adult plasticity can be modulated within a short time period (hrs) to restore binocular function lost during childhood.

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Amblyopia (lazy eye) is the most common form of unilateral blindness in the adult population and results from a disruption to normal visual development early in life.

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